Vanguard University's academic structure is organized by different areas of study. Twenty traditional undergraduate majors, four adult education undergraduate degrees, and four graduate degrees are housed within the following areas:
The School for Professional Studies offers adult learners degrees in business, nursing, psychology, and religion, as well as a minor in liberal studies and general education courses. Aside from taking classes in their own major, students in the traditional undergraduate program are also required to take classes that are part of the core curriculum.